Infertility Due to Endometrial hypoplasia
While a number of health and lifestyle factors can cause female infertility, one of the most common causes is Endometrial hypoplasia which resulted in malfunction of endometrial cells.
What is Endometrial hypoplasia?
There are two common causes
Asherman’s Syndrome (AS) an acquired condition where the uterus is damaged by repeated abortions, curettage procedures, or endometriosis
Endometrial Atrophy (EA) a presumed effect of contraceptive pills and Tamoxifen where the lining of the endometrium is reduced to 5 mm or less in thickness
Whichever the cause, endometrial hypoplasia poses an obstacle to conceiving, as it prevents successful embryonic attachment.
How stem cell increase the endometrial wall
Because of their ability to heal or replace damaged cells, stem cells have also proven successful in increasing endometrium thickness for those struggling with infertility.
The examples of successful researches of stem cell therapy in AS and EA
Remark:
The studies found that stem cell therapy significantly increased the endometrium thickness by from 3–5 mm to 7 mm and reported no dangerous effects.
References:
Jinchun Tan, Pingping Li, Qiushi Wang, Yaxuan Li, Xiaoni Li, Dongni Zhao, Xiaoyan Xu and Lin Kong, Autologous Menstrual Blood-Derived Stromal Cells Transplantation for Servere Asherman’s Syndrome, Human Reproduction (2016) : 31(12) : 2723-2729
Xavier Santamaria, Sergio Cabanillas, Irene Cervello, Cristina Arbona, Francisco Raga, Jaime Ferro, Julio Palmero, Jose Remohi, Antonio Pellicer and Carlos Simon, Autologous Cell Therapy with CD133+ Bone Marrow-Derived Stem Cells for Refractory Asherman’s Syndrome and Endometrial Atrophy: A Pilot Cohort Study, Human Reproduction (2016): 31(5): 1087-1096
Chaitanya B Nagori, Sonal Y Panchal and Himanshu Patel, Endometrial Regeneration Using Autologous Adult Stem Cells Followed by Conception by In Vitro Fertilisation in a Patient of SevereAsherman’s Syndrome, Journal of Human Reproductive Science (2010):4(1):43-48